Treatment of solid tumors with immunotoxins
نویسندگان
چکیده
منابع مشابه
The spatial distribution of immunotoxins in solid tumors: assessment by quantitative autoradiography.
The spatial distribution of i.v. administered immunotoxins in s.c. human rhabdomyosarcoma RD2 xenografts was studied. The toxin and immunotoxins were: (a) diphtheria toxin (DT); (b) a binding-deficient form of DT (CRM107) linked to a monoclonal IgG1 antibody (454A12) directed against the human transferrin receptor (454A12-107); (c) the binding-deficient form of DT linked to the Fab' fragment of...
متن کاملEffect of Antigen Shedding on Targeted Delivery of Immunotoxins in Solid Tumors from a Mathematical Model
Most cancer-specific antigens used as targets of antibody-drug conjugates and immunotoxins are shed from the cell surface (Zhang & Pastan (2008) Clin. Cancer Res. 14: 7981-7986), although at widely varying rates and by different mechanisms (Dello Sbarba & Rovida (2002) Biol. Chem. 383: 69-83). Why many cancer-specific antigens are shed and how the shedding affects delivery efficiency of antibod...
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چکیده ندارد.
15 صفحه اولTreatment of hematologic malignancies with immunotoxins and antibody-drug conjugates.
To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-drug conjugates, respectively, represent a second revolution in antibody-mediated cancer therapy. Thus, highly toxic compounds are delivered to the interior of cancer cells based ...
متن کاملEvaluation of a Novel Thermobrachytherapy Seed for Concurrent Administration of Brachytherapy and Magnetically Mediated Hyperthermia in Treatment of Solid Tumors
Concurrent hyperthermia and radiation therapy in treatment of cancer show a strong evidence of a synergistic enhancement. We designed a new self-regulating Thermo-Brachytherapy seed, which serves as a source of both radiation and heat for concurrent administration of brachytherapy and hyperthermia. The Thermo-Brachytherapy seed has a core of ferromagnetic material which produces heat when subje...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2005
ISSN: 1465-542X
DOI: 10.1186/bcr1284